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Research Enterprise Newsletter

The Office of the Vice Chancellor for Research (OVCR) publishes the RESEARCH ENTERPRISE to keep the academic community and the community at large informed about research activities, opportunities and development on the IUPUI campus.

Research Offices:
Development
Administration
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Enterprise Archive


Editor:
Etta Ward

Layout:
Fred Haver


If you have a news item or recent noteworthy research-related achievement that you would like to share, please see the Research Enterprise Submission Guidelines.

Please be aware that not all news items will be deemed appropriate or timely for publication, but each item will be carefully considered.

August 14, 2014

INSIDE THIS ISSUE:

FEATURE STORY

IUPUI Awarded National Science Foundation Instrumentation Grant to Enhance Interdisciplinary Research Profile and Strengthen STEM Education

Mangilal Agarwal, Ph.D.

Mangilal Agarwal, Ph.D

Gregory Druschel, Ph.D.

Gregory Druschel, Ph.D.

The National Science Foundation (NSF) has awarded Indiana University-Purdue University Indianapolis (IUPUI) a $374,989 grant to purchase an advanced X-Ray Diffraction (XRD) system, through the Major Research Instrumentation Program. The XRD system, which will be housed in and maintained by the Integrated Nanosystems Development Institute (INDI) in collaboration with the Department of Earth Science, enhances IUPUI’s shared instrumentation profile, and supports faculty and students across many schools and departments by providing capabilities for a range of interdisciplinary scientific discovery and workforce training.

“The XRD system will support the research of several interdisciplinary faculty researchers, including junior faculty members whose career development will be greatly advanced by the granted XRD system,” said Mangilal Agarwal, INDI’s director and co-principle investigator. “We’re extremely grateful to the National Science Foundation for their investment and excited about the many benefits it will not only bring to IUPUI, but to the community at large.”

This powerful instrumentation will increase the ability of investigators at IUPUI to characterize the properties of solid materials, especially of nanoscale-size, for fundamental research projects that provide the basis for applications in Earth Sciences (ore and energy deposits, water quality, and minerals impacts on human health), Nanotechnology (new materials development for energy, industry, and biomedical applications), and Biophysical research (biological membrane function in biomaterials including amino acids, detergents, and pharmaceuticals).

“This grant reflects the strong collaborative environment for interdisciplinary research at IUPUI. The Schools of Science, Engineering and Dentistry frequently collaborate in research with significant impact on all aspects of our mission (including teaching) and on the local economy,” said Simon Rhodes, Dean of the School of Science.

» Read more...

 

ANNOUNCEMENTS

IUPUI Imaging Research Symposium October 3

Kamlesh Lulla, Ph.D.

Kamlesh Lulla, Ph.D.
NASA Johnson Space Center

The IUPUI Imaging Research Symposium will be held on October 3, 2014, from 10:00 am to 3:10 pm, in the IUPUI University Library Lilly Auditorium. The objective of this Symposium is to bring together investigators from diverse scientific disciplines with imaging technology experts to explore potential collaborative research opportunities. Register today at Imaging Symposium 2014.

This year’s event will include a presentation by Dr. Kamlesh Lulla, Chief Scientist for Earth Observations from NASA’s Johnson Space Center, who will describe recent activities in remote imaging. In addition, several IUPUI investigators will present their imaging-related research activities. These include applications in neuroimaging in Alzheimer’s disease, 3D imaging of the human airway, live cell imaging, and molecular probe development for tumor imaging, among other topics. A poster session will provide the opportunity for attendees to interact with several investigators who develop or utilize imaging technologies in their research.

The target audience includes researchers within the IUPUI/IU/PU community as well as academic and industrial investigators within the greater Indiana research community. To learn more about the IUPUI Imaging Research Initiative, go to http://www.imaging.iupui.edu/index.php.

School of Medicine Professor Receives Prestigious Award

Daniel Rusyniak, M.D.

Daniel Rusyniak, M.D.

Daniel Rusyniak, associate professor of emergency medicine, has been awarded the American College of Medical Toxicology's 2014 Outstanding Contribution to Medical Toxicology.

Dr. Rusyniak was recognized for his role in advancing the scientific understanding of methamphetamines, including developing new techniques to detect methamphetamines, and contributions to the understanding of the mechanism by which amphetamines cause life-threatening hyperthermia.

His research has been recognized by a Mentored Clinical Scientists Development Award (K08) and Research Project Grant Program (R01) award from National Institutes of Health, making him one of only a handful of medical toxicologists with NIH funding, according to the ACMT.

Dr. Rusyniak also serves as the vice chair of faculty development in the Department of Emergency Medicine at the IU School of Medicine.

School of Science Professor Just One of 13 Jefferson Science Fellows in the Country

Gabriel Filippelli, Ph.D.

Gabriel Filippelli, Ph.D.

Time spent in the Peace Corps has shaped a lifetime of work for Dr. Gabriel Filippelli.

It worked that way for Dr. Filippelli. The School of Science faculty member’s two-year Peace Corps term on a small island atoll in the Pacific Ocean convinced him that studying the role of Earth’s oceans on our environment would be a career worth pursuing.

That career path has put Dr. Filippelli in some prominent professional circles. He is one of just 13 scientists and engineers from across the U.S. to serve as a Jefferson Science Fellow, a program that connects American universities with the U.S. State Department on matters related to the climate and the environment.

His island time profoundly affected Dr. Filippelli and still shapes his worldview.
“Surrounded by oceans on all sides, I came to appreciate more deeply the role that oceans play in not only feeding people but also in influencing global climate, in the past, at present, and into the future,” he said.

That’s one of the reasons Dr. Filippelli has spent much of his career researching climate change and other environmental issues. And for the past decade, he has been an advisor to the Integrated Ocean Drilling Program, a long-term effort that studies the history of the Earth as recorded in sediment and rocks beneath the sea floor.

It also influences his work with the State Department and has given him a greater appreciation of the potential impact of his work.

“My affiliation with the State Department has transformed my understanding of the fundamental role of science in foreign policy,” he said. “I have worked closely with science leaders in NASA, NOAA, the National Science Foundation and other federal and international agencies to craft and approve important new policies for environmental protection.”

Gabriel Filippelli, Ph.D.

As part of his work for the U.S. State Department, Gabriel Filippelli, far right, met with the President of Kiribati, far left, at a diplomatic luncheon hosted by the secretary of state.

Filippelli considers the work vital in an era that he expects will feature significant climate change. He also believes the team’s work will enhance his teaching of IUPUI students.

“This is the first generation of students to fully understand that humans are fundamentally changing the flows of earth, air and water around the planet,” Dr. Filippelli said. It also is playing a role in people’s health.

The researcher also is the director of the Center for Urban Health at IUPUI, a collaboration linking the School of Science, the School of Liberal Arts, the School of Medicine and the Richard M. Fairbanks School of Public Health.

“The core principle of the Center for Urban Health is to integrate the spheres of environment, community, and health into one consortium,” Dr. Filippelli said. “It can serve as a training and research think tank, where, for example, a water scientist, a public health expert and a community leader can work together to improve the health and beauty of a neighborhood stream, opening it up to creative, educational, and economic opportunities not otherwise achievable.”

 

CENTER SPOTLIGHT

Komen Bank Part of Major Study

Chunyan He, Ph.D.

Chunyan He, Ph.D.

More than 160 institutions were involved in an international project, published today in the journal Nature, proving that the age at which girls reach sexual maturity can be influenced by either parent. This is the first time it has been shown that imprinted genes -- a process of temporarily silencing the genes of one parent -- can control the rate of development after birth.

The findings come from an international consortium study involving scientists from 166 institutions worldwide, including Indiana University. The researchers identified 123 genetic variations that were associated with the timing of when girls experienced their first menstrual cycle by analyzing the DNA of 182,416 women of European descent from 57 studies.

Indiana University genetic epidemiologist Chunyan He, Sc.D., is one of the 10 lead authors of the consortium article. A member of the Indiana University Melvin and Bren Simon Cancer Center and an assistant professor at the IU Richard M. Fairbanks School of Public Health, Dr. He’s research for this paper was made possible by the Komen Tissue Bank at the IU Simon Cancer Center, the only bank of normal breast tissue in the world.

Dr. He said 300 healthy tissue samples from the Komen Tissue Bank and 300 samples of malignant breast tissue from the IU Simon Cancer Center Tissue Procurement and Distribution Core were genotyped and analyzed for the data she contributed to the Nature article. This is one of the largest studies using Komen Tissue Bank samples to date, she said. The one-of-a-kind healthy tissue bank at IU was established in 2005 and supported by Susan G. Komen since 2007. Nearly 10,000 women have contributed healthy blood or breast tissue to aid research into the causes of and treatments for breast cancer. Anna Maria Storniolo, M.D., is executive director of the Komen Tissue Bank at the IU Simon Cancer Center.

» Read more...

 

FACULTY SPOTLIGHT

IUPUI Mathematician Receives Prestigious NSF Early Career Development Award

Roland Roeder, Ph.D.

Roland Roeder, Ph.D.

Roland Roeder, a mathematician from the School of Science, will receive $460,000 over the next five years from the National Science Foundation’s Division of Mathematical Sciences to support his research in pure math and the training of students from the graduate to high school levels.

The Faculty Early Career Development award is the NSF's most prestigious award in support of junior faculty. It is given to individuals who “exemplify the role of teacher-scholars through outstanding research, excellent education and the integration of education and research.”

The award will support Dr. Roeder’s research on dynamics in several complex variables, an area of pure mathematics focusing on the theoretical underpinnings of systems that change with time.

“Systems that change with time appear at the core of nearly all scientific endeavors, including biology, chemistry, physics and the social sciences," he noted. "Given the current state of a system, can one predict its future state? How does this evolution of the state of the system depend on the parameters of the system?

» Read more...

 

STUDENT SPOTLIGHT

Student Researcher's Work Published in Annals of Internal Medicine

Laura Vater

Laura Vater

A study by an IU School of Medicine-South Bend student has attracted attention from national media outlets such as CNN, WebMD and Modern Health Care.

Laura Vater, a second-year student at IUSM-South Bend, is the lead author on a study in the Annals of Internal Medicine analyzing cancer center advertisements that emphasize fear and hope on television and in popular magazines.

“With these cancer center advertisements, patients are getting the rose-colored glasses version: ‘If you come to our center, you’re going to live,'" Vater said.

The paper presents evidence that cancer patients may have had the quality of their treatment altered before it begins, influenced by a cancer center.

The study, titled "What Are Cancer Centers Advertising to the Public? A Content Analysis," argues that that cancer center marketing drives a demand for therapies such as chemotherapy and radiation through emotional messaging that is "long on happy endings or battle cries, but short on information" about treatment option risks and benefits, costs, and potential alternatives.

» Read more...

 

TRANSLATIONAL RESEARCH IMPACT

Study: Four Habits Model Prepares Pediatric Nurses for Emotionally Difficult Discussions

Richard M. Frankel, Ph.D.

Richard M. Frankel, Ph.D.

A child's illness and hospitalization are extremely stressful for both the child and the parents. A new study reports that the Four Habits Model of Highly Effective Clinicians, a core set of communication skills developed to help physicians communicate with patients, can successfully prepare inexperienced nurses for emotionally difficult conversations with parents of pediatric patients.

The evidence-based Four Habits Model was co-developed 20 years ago by Regenstrief Institute investigator Richard Frankel, Ph.D., a sociologist and medical educator whose current research focuses on facilitating and improving clinician-patient communication in the context of advanced cancer. This is the first time the Four Habits Model's effectiveness has been tested with nurses.

The new study, published in the July 2014 issue of Patient Education and Counseling, found that when taught the Four Habits Model, newly licensed nurses reported significant improvements in emotion-focused conversations with parents in four of the five areas measured: preparation, communication skills, relationships and confidence.

"Newly minted nurses, like other newly trained professionals, tend to concentrate on getting the work done," Dr. Frankel said. "Getting the work done is obviously important to patient care, but so is being thoughtful and reflecting on what one is doing, not simply operating in the moment. We don't do a lot of real-world training of nurses, doctors or any type of health professional; we put them in classrooms and provide simulations exercises but don’t really give them on-the-job coaching or opportunities to practice important communication and other skills. With exposure to the Four Habits, inexperienced nurses can improve how they interact with both young patients and their parents."

» Read more...

 

OVCR Internal Grant Deadlines

Enhanced Mentoring Program with Opportunities for Ways to Excel in Research (EMPOWER):
The Enhanced Mentoring Program with Opportunities for Ways to Excel in Research (EMPOWER) has been developed to support IUPUI faculty who are historically underrepresented and/or excluded populations in their discipline or area of scholarship and historically denied admission to higher education or that discipline, 1) to become successful in sponsored research and scholarly activity, and 2) to achieve significant professional growth and advancement. The program sustains mentorship opportunities through the EMPOWER Grant Program, supporting achievement of excellence in research and scholarly activity, and optimal attainment of academic career goals and objectives. The next EMPOWER application deadline is September 5, 2014. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

Funding Opportunities for Research Commercialization and Economic Success (FORCES):
The FORCES program is designed to support IUPUI researchers in the successful transformation of their research findings into commercially viable outcomes. The key goals of FORCES are to support: 1) realization of short-term projects that will enhance commercial value of IUPUI intellectual property assets, by facilitating commercialization of inventions, technologies, or other intellectual property derived from existing research projects, and 2) development of research initiatives that show great promise for commercialization of the research outcomes. The next RTR application deadline is September 15, 2014. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

(NEW PROGRAM) Imaging Technology Development Program (ITDP):
The objective of the Imaging Technology Development Program (ITDP) is to provide a source of seed funding to foster multidisciplinary research activities to advance the development of new, innovative, imaging-related technologies, defined as any technology associated with the acquisition of images, display of image information, or quantitative analyses of the information contained within an image. The ITDP application deadline is October 1. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

(NEW PROGRAM) IUPUI Graduate Student Imaging Research Fellowship (GSIRF) Program:
The aim of the IUPUI Graduate Student Imaging Research Fellowship (GSIRF)Program is to provide a stable source of funding for graduate students pursuing a doctoral degree focused on imaging technology development within an interdisciplinary, collaborative, research environment. Furthermore, it is anticipated that this program will serve as a means to enhance multidisciplinary research activities among senior investigators. It is expected that the funded GSIRF projects will provide the foundation for securing additional external funding sources to further the new imaging technology and its utilization within the mentors’ laboratories. The GSIRF application deadline is October 15. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

Research Support Funds Grant (RSFG):
The Research Support Funds Grant (RSFG) program is designed to enhance the research mission of IUPUI by supporting research projects and scholarly activities that are sustainable through external funding. The next RSFG application deadline is October 15, 2014. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

International Development Fund (IDF) GRANT:
The IDF grant was developed to enhance the international research and scholarly activity focus of the IUPUI academic mission. Generally, the IDF grant serves as venture capital to stimulate additional funding for international research and scholarly activity, which have strong potential to generate indirect cost recovery from extramural sources. The next IDF application deadline is November 15, 2014. For grant guidelines and application forms, go to http://research.iupui.edu/funding/.

 

Other Internal Grant Deadlines

Research Proposals Sought for New Consortium

Faculty members interested in funding for research proposals through the IU Consortium for the Study of Religion, Ethics and Society still have time to submit a proposal.

This is the first call for research proposals from the new consortium. The research proposals are part of the first phase of a two-year thematic initiative -- “Wonder and the Natural World” -- sponsored by the consortium.

Funding of up to $5,000 for individuals and up to $10,000 for teams is available. Full-time, tenure-track IU faculty members from any IU campus are eligible to apply, with proposals that cut across disciplines, units, or campuses especially welcome.

The IU Consortium for the Study of Religion, Ethics and Society is an interdisciplinary association of scholars, academic programs, and research centers from the eight campuses of Indiana University. The consortium was launched in January 2014 to leverage IU’s strengths in the interdisciplinary study of religion and advance research in key thematic areas.

The deadline for proposals is September 1. Funding awards will be announced at the end of October. Recipients will present their preliminary findings and works-in-progress at a daylong symposium at IU Bloomington in May 2015.

The full call for proposals may be found online on the Department of Religious Studies website. Proposals should be emailed to Abby Gitlitz at agitlitz@indiana.edu. For additional information on the consortium or the funding awards, contact Lisa Sideris at lsideris@indiana.edu.

 

OVCR Events and Workshops

OVCR Research Orientation

Target Audience: Faculty

When: Wednesday, August 27, 2014 | 1:00pm - 3:00pm
Where: University Library, Room 1116

This session will provide an overview of research resources, services and support offered to IUPUI faculty by the Office of the Vice Chancellor for Research. Participants will also meet with some current IUPUI faculty members to hear how they were able to achieve success in the early stages of their tenure at IUPUI.

Register: https://crm.iu.edu/CRMEvents/OVCROrientation082714/

OVCR Research Orientation (Repeat Session)

Target Audience: Faculty

When: Friday, September 5, 2014 | 10:00am - 12:00pm
Where: University Library, Room 1126

This session will provide an overview of research resources, services and support offered to IUPUI faculty by the Office of the Vice Chancellor for Research. Participants will also meet with some current IUPUI faculty members to hear how they were able to achieve success in the early stages of their tenure at IUPUI.

Register: https://crm.iu.edu/CRMEvents/OVCROrientationRepeat090514/

Finding Funding

Target Audience: Faculty, Staff, Graduate Students

When: Tuesday, September 23, 2014 | 2:00pm - 3:30pm
Where: University Library, Room 0106

This session will provide an overview of the various types of external funding sources, identify tools to locate funding opportunities, explain how to design a funding search, and demonstrate a couple of knowledge management systems that contain thousands of funding opportunities available by the university subscription. This session is hands-on in a computer lab.

Register: https://crm.iu.edu/CRMEvents/FindingFunding092314/

Basic Proposal Development

Target Audience: Faculty and department or school grants administrators

When: Thursday, September 25, 2014 | 11:30am - 1:00pm
Where: University Library, Room 1126

This workshop will focus on the basic essentials of building a successful grant proposal for agencies that fund in health, science, engineering, informatics, technology, and social sciences. A wide-range of topics will be covered from developing a strong foundation for your application to key components of the narrative, the basic budget, writing styles, and interpreting agency guidelines, the necessity for knowing how your proposal will be reviewed, funding limitations, and how to communicate complex ideas in a limited space. You are welcome to bring your lunch.

Register: https://crm.iu.edu/CRMEvents/BasicProposalDev092514/

Nine Golden Rules to Succeed in Research and Scholarship

Target Audience: Faculty

When: Friday, October 31, 2014 | 11:00am - 1:00pm
Where: University Library, Room 1126

This session will reveal the Nine Golden Rules on how to succeed in research and scholarship. It is focused toward new and early career investigators; however, mid career faculty should find information of interest as well.

Register: https://crm.iu.edu/CRMEvents/NineGoldenRules103114/

Ins and Outs of Applying for NIH Funding

Target Audience: Faculty and grant administrators

When: Friday, November 7, 2014 | 9:00am - 12:00pm
Where: University Library, Lilly Auditorium

How to prepare and submit grant proposals to the National Institutes of Health (NIH) is the focus of presentations by representatives of the Office of the Vice Chancellor for Research, the Office of Research Administration and NIH awardees on the IUPUI faculty. The workshop will provide an overview of the Institutes, their mission, priorities and NIH programs that cut across disciplines. Specific topics include a description of the various funding mechanisms and their appropriateness for each career stage, attributes of high quality proposals, and resources available within the University to support proposal development. Highlighting the event is a panel discussion by current NIH reviewers who will provide an in-depth look into the peer review process.

Register: https://crm.iu.edu/CRMEvents/NIHFunding110714/

Developing Complex, Multi-Investigator, Multi-Institutional Proposals

Target Audience: Senior Faculty with Previous External Funding

When: Thursday, November 13, 2014 | 11:30am - 1:00pm
Where: University Library, Room 1126

The current funding environment favors large, complex, multi-institutional, multi-investigator projects. However, organizing a successful submission takes a great deal of planning and teamwork. What works best in which situation? Should you use a “Red Team Review”? What role does the RFP serve to organize the writing efforts? Professional proposal writers and editors will discuss these and a number of related issues at this session. You are welcome to bring your lunch.

Register: https://crm.iu.edu/CRMEvents/ComplexProposals111314/

 

Other Events and Workshops

IUPUI Arts and Humanities Institute (IAHI) Fall 2014 Lineup

For more details and to register, visit http://www.iupui.edu/~iahi/?page_id=39.

Grant Writing Workshop: IU New Frontiers in the Arts and Humanities Grant Program

DATE: September 3, 2014
TIME: 12:00 PM – 1:30 PM
LOCATION: IUPUI Arts and Humanities Institute, Conference Room, University Library 4th Floor

This session will provide participants with an overview of the IU New Frontiers in the Arts and Humanities Grant Program. It will offer information on how to apply and, more importantly, how to develop a competitive proposal. Faculty recipients and members of the New Frontiers grants advisory groups will be present to answer questions.

Register

Sixth Annual Indiana CTSI Meeting -- September 26

Mark your calendars! The sixth annual meeting of the Indiana Clinical and Translational Sciences Institute will be Friday, September 26, at the Hine Hall Auditorium on the IUPUI campus in Indianapolis.

This free event is an opportunity to learn more about the Indiana CTSI, participate in poster presentations and breakout sessions, and meet new colleagues and collaborators. Anyone who wants to learn more about the Indiana CTSI is welcome.

Additional information will be posted to the Indiana CTSI HUB. Questions can be directed to info@indianactsi.org
 

CURRENT EXTERNAL FUNDING OPPORTUNITIES

Funding opportunities in this section include selected current grant announcements from federal agencies for new initiatives and changes to existing programs. Announcements with limited scope are not listed here but instead are sent directly to IUPUI School Deans. For comprehensive coverage of funding opportunities, please use the online search tools listed below.

DEPARTMENT OF DEFENSE

Medical Clinical and Rehabilitative Medicine Research Program-Reconstructive Transplantation Research Award: This opportunity challenges the scientific community to design innovative research that will foster new directions for and address neglected issues in the field of reconstructive transplantation (RT), specifically vascularized composite allotransplantation (VCA)-focused research, also known as composite tissue allotransplantation (CTA). VCA refers to the transplantation of multiple tissues such as muscle, bone, nerve, and skin, as a functional unit (e.g., a hand or face) from a deceased donor to a recipient with a severe injury. Applications from investigators within the military Services and applications involving multidisciplinary collaborations among academia, industry, the military Services, the Department of Veterans Affairs (VA), and other Federal Government agencies are highly encouraged. Though the RTR Award mechanism supports groundbreaking research, all projects must demonstrate solid scientific rationale with military-relevant utility. The intent of the RTR Award is to support projects that will accelerate the movement of promising ideas in RT into clinical application. The mechanism is intended to support both new and established scientists across a broad spectrum of disciplines in research projects that are likely to have a major impact on RT. Deadlines: Pre-application: October 15, 2014; Application: October 29, 2014.


NOTE: All faculty, researchers, and scientists on continuing contracts at IU interested in applying for Department of Defense funding are eligible for assistance by the consulting firm Cornerstone Government Affairs, arranged by the Vice President for Research. Those interested in securing assistance from Cornerstone must submit a two-page summary of their research project and a CV or bio sketch to the VP for Research Office at vpr@iu.edu . Prior to submission, the IUPUI Office of the Vice Chancellor for Research is offering preparation assistance with the two-page summaries. For more information, contact Ann Kratz, akratz@iupui.edu.

NATIONAL ENDOWMENT FOR THE HUMANITIES

Digital Projects for the Public: NEH's Division of Public Programs supports activities that engage millions of Americans in understanding significant humanities works and ideas. At the center of every NEH-funded public humanities project is a core set of humanities ideas developed by scholars, matched to imaginative formats that bring humanities ideas alive for people of all ages and all walks of life. The Digital Projects for the Public program supports projects such as websites, mobile applications, games, and virtual environments that significantly contribute to the public's engagement with humanities ideas. Projects must be analytical and deeply grounded in humanities scholarship in a discipline such as history, religion, anthropology, jurisprudence, or art history. Digital Projects for the Public grants support projects that are largely created for digital platforms. While these projects can take many forms, shapes, and sizes, you should apply to this program primarily to create digital projects or the digital components of a larger project. NEH is a national funding agency, so these projects should demonstrate the potential to attract a broad, general audience. Projects can have specific targeted audiences (including K-12 students), but they should also strive to cultivate a more inclusive audience. Deadline: June 11, 2015.

NATIONAL INSTITUTES OF HEALTH

Immune and Inflammatory Mechanisms in Alzheimer’s Disease (R01): The goal of this FOA is to establish the role of the brain innate immune system, the systemic immune system, and the crosstalk and changes with age between the two in the development and progression of Alzheimer's disease (AD). An interdisciplinary and integrative research approach to identify the cell networks and meditators of the brain and systemic immune and inflammatory systems is expected to give greater insight into the etiological mechanisms underlying Alzheimer's disease. Such characterization should include studies on the genetic, epigenetic, molecular and cellular underpinnings of the physiological immune and inflammatory responses in AD. Development of cell or functional markers of, and tools to manipulate or track peripheral and CNS immune cells, would help establish the role of distinct immune cells in AD. The contribution of aging processes in the brain (e.g., microglial senescence) and in peripheral immune/inflammatory networks (e.g., chronic low level inflammation) in the initiation and/or progression of AD should be considered. Applicants to this FOA must emphasize the multidisciplinary and integrative research approaches taken to identify the cell networks, mediators, and pathways of the brain and systemic immune and inflammatory systems that influence the development and progression of AD.

Areas of research interest include, but are not limited to: 1) Characterize in a systematic, integrative way the cell networks-monocytes, macrophages, microglia, astrocytes, neurons and signaling factors that regulate brain immune/inflammatory function across the AD spectrum. 2) Identify genetic, epigenetic and molecular pathways, including function of AD risk gene loci, mediating immune/inflammatory networks in AD. Are pathway changes drivers of disease or in response to AD pathophysiology? 3) Compare, in a limited manner, immune/inflammatory processes in AD with other age-related neurodegenerative diseases to identify AD-specific mechanisms. 4) Establish the crosstalk between systemic and brain immune systems-cells, intercellular activators and mediators, effector functions in AD. Consider when and where crosstalk occurs. 5) Define the contribution of age-associated chronic inflammation, immune cell senescence, and/or immune system deficits as comorbidity factors in AD. Deadlines: December 29, 2014, letter of intent; January 29, 2015, submission.

Stem Cells and Alcohol-Induced Tissue Injuries (R01): This opportunity encourages applications to study human and non-human stem cells involved in alcohol-induced tissue injuries. Alcohol abuse is known to cause pathology in a number of organ systems. Disorders most commonly associated with chronic alcohol consumption include alcoholic liver disease (ALD), pancreatitis, cardiovascular disease, neural damage, endocrine dysfunction, osteoporosis, cancer, and immune dysfunction. The objective of this FOA is to understand the role of stem cells in alcohol-induced tissue damage and recovery, particularly how they are influenced by alcohol metabolism and their role in alcohol-related cancers. Deadline: February 5, 2015.

Development of Mathematical Cognition and Reasoning and the Prevention of Math Learning Disabilities (R01): This opportunity is intended to stimulate innovative, multidisciplinary research on the cognitive, neuroplasticity, genetic and environmental factors involved in math learning and learning disabilities. This research will advance our knowledge of the factors that contribute to the development, advancement, and impairment of mathematical cognition, including the ability to apprehend and reason about magnitude, number, temporal and spatial relationships, and concomitantly provide the evidence base to inform the design of effective interventions for the remediation and/or prevention of mathematical learning disabilities (MLD). The overall objectives include: 1) identifying the critical biological, cognitive, and behavioral components and dynamic developmental sequence, including sensitive periods, necessary for the normal development of mathematical cognitive abilities and reasoning, including early and normative milestones; 2) identifying the biological, cognitive, environmental, and behavioral factors that contribute to and/or restrict the developmental plasticity of mathematical cognitive abilities, and may be used to improve prevention, identification, and classification of children, including theoretically-grounded approaches to identification and classification; 3) developing and testing well-defined, evidence-based prevention interventions for populations at high risk for mathematics learning disability such as children raised in poverty, and those with predisposing genetic or medical conditions where the intervention's effectiveness can be shown to be both sustainable and generalizable; and 4) developing and testing well-defined, evidence-based remediating or treatment interventions, the effectiveness of which can be demonstrated to be both sustainable and generalizable. Such foundational knowledge should ultimately improve math instruction, both for typically developing and math challenged or disabled children. Deadline: October 5, 2014.

NATIONAL SCIENCE FOUNDATION

Interdisciplinary Behavioral and Social Science Research (IBSS): The IBSS competition establishes new opportunities to encourage, facilitate, and support interdisciplinary research that brings together researchers from different Social, Behavioral, and Economic Sciences (SBE) disciplinary communities. It will focus on research problems that can be fully addressed only by interdisciplinary teams using approaches from multiple fields, and it will support research that promises results that will be meaningful across the contributing disciplines and that will explicitly advance science beyond existing intellectual boundaries. The IBSS competition seeks to support research conducted by SBE scientists as collaborating members of teams that come from multiple disciplines, who engage in integrated research that employs methods and techniques from multiple disciplines, and whose results are likely to enhance theories and/or methodological approaches or have other stimulating and/or catalytic impact across a range of disciplinary fields.

The IBSS competition invites proposals for two different kinds of projects: 1) IBSS Large Interdisciplinary Research Projects; and 2) IBSS Interdisciplinary Team Exploratory Projects.Support for exploratory efforts by emerging multidisciplinary teams is designed to facilitate the kinds of contact, interaction, and active research activities necessary to enable researchers from multiple disciplines to engage in effective interdisciplinary research. Emphasis is to be placed on the conduct of research and potential outcomes, not on the preparation of plans and proposals for future research. Proposals seeking IBSS support may address any topic, issue, or problem. Researchers are encouraged to pursue research on one of the four cross-cutting themes identified in the Rebuilding the Mosaic report (population change; sources of disparities; communication, language, and linguistics; and technology, new media, and social networks), but the IBSS competition will be open and receptive to other topics that address topics having theoretical and societal significance. Deadline: December 2, 2014.

Alan T. Waterman Award: This award is the highest honor awarded by NSF. Since 1975, when Congress established it to honor the agency's first director, this annual award has been bestowed upon individuals who have demonstrated exceptional individual achievement in scientific or engineering research of sufficient quality to place them at the forefront of their peers. The annual award recognizes an outstanding young researcher in any field of science or engineering supported by NSF. Deadline: October 25, 2014.

Expeditions in Training, Research, and Education for Mathematics and Statistics through Quantitative Explorations of Data (EXTREEMS-QED): The long-range goal of EXTREEMS-QED is to support efforts to educate the next generation of mathematics and statistics undergraduate students to confront new challenges in computational and data-enabled science and engineering (CDS&E). EXTREEMS-QED projects must enhance the knowledge and skills of most, if not all, the institution's mathematics and statistics majors through training that incorporates computational tools for analysis of large data sets and for modeling and simulation of complex systems.

Funded activities are expected to: 1) provide opportunities for undergraduate research and hands-on experiences centered on CDS&E; 2) result in significant changes to the undergraduate mathematics and statistics curriculum; 3) have broad institutional support and department-wide commitment that encourage collaborations within and across disciplines; 4) include professional development activities for faculty or for K-12 teachers; and 5) where appropriate, leverage and advance the use of existing cyberinfrastructure resources (e.g., data archives, networks) for data exploration.

The Office of Cyberinfrastructure is interested in supporting educational activities that incorporate cyberinfrastructure considerations at a fundamental level, and in efforts that leverage and advance NSF cyberinfrastructure investments. Cyberinfrastructure consists of advanced computing systems, data storage systems, instruments and data repositories, visualization environments, and people, all linked together by software and high performance networks to improve research productivity and enable breakthroughs not otherwise possible. Deadline: November 6, 2014.

U.S. DEPARTMENT OF ENERGY

Resilience for Extreme Scale Supercomputing Systems: Proposals are invited for basic research that significantly improves the resiliency of scientific applications in the context of emerging architectures for extreme scale computing platforms. The next-generation of scientific discovery will be enabled by research developments that can effectively harness significant or disruptive advances in computing technology. Applications running on extreme-scale computing systems will generate results with orders of magnitude, higher resolution and fidelity, achieving a time-to-solution timeline significantly shorter than possible with today's high performance computing platforms. However, indications are that these new systems will experience hard and soft errors with increasing frequency, necessitating research to develop new approaches to resilience that enable applications to run efficiently to completion in a timely manner and achieve correct results. Of interest are proposals that address challenges in the following topics: 1) Fault Detection and Categorization: 2) Fault Mitigation; 3) Anomaly Detection and Fault Avoidance. Deadline: November 3, 2014.

 

IDENTIFYING FUNDING OPPORTUNITIES

On-line search tools are available to IUPUI investigators who are interested in identifying funding opportunities in their areas of interest.

Community of Science (COS): COS is a primary on-line search tool for identifying funding opportunities. To take advantage of this tool, register at http://www.cos.com/login/join.shtml. Once you have completed the short registration process, you can personalize your search by selecting the option entitled “launch your workbench”. You can access federal, local, corporate, foundation, nonprofit and other funding opportunities using key terms and save the results of up to 20 searches and have them delivered to you weekly via email.

National Institutes of Health (NIH) “NIH Guide”: To take advantage of this search tool, register at http://grants.nih.gov/grants/guide/listserv.htm. It allows you to receive discipline specific funding opportunities that are delivered to you weekly via email.

National Science Foundation (NSF) “MyNSF”:To take advantage of this search tool, register at http://service.govdelivery.com/service/multi_subscribe.html?
code=USNSF&custom_id=823
. It allows you to receive discipline specific funding opportunities that are delivered to you weekly via email.

Federal Business Opportunities “FedBizOpps”: FedBizOpps is the single government point-of-entry for Federal government procurement opportunities over $25,000. To take advantage of this search tool, visit https://www.fbo.gov. Opportunities found at this site include, but are not limited to, presolicitations and special notices for research and service contracts for specific projects and some national centers and surveys that would not be found in Grants.gov and may not be found in the Community of Science.

Limited Submission Funding Opportunities:

Many federal agencies and foundations offer grants, awards and fellowships that limit the number of applications that can come from one institution or require special handling. In order to comply with agency and foundation guidelines and increase the chances of Indiana University (IU) succeeding in such limited submissions and special handling opportunities, IU policies and procedures are in place and are utilized by the Office of the Vice Chancellor for Research and other IU research offices to facilitate internal coordination and competitions.

Individuals interested in responding to limited submission opportunities must inform the Office of the Vice Chancellor for Research about their intent to apply to a given limited submission opportunity, such that they can be included in the internal review and selection process. Failure to do so may disqualify individuals from consideration for submission to the funding opportunity.

Individuals interested in a limited submission opportunity or have any questions about the internal coordination process, contact Etta Ward at emward@iupui.edu or 317-278-8427. For a description of upcoming limited submission funding opportunities, as well as guidelines and application forms, go to: http://research.iu.edu/limited_sub.shtml. Please note that this is not a comprehensive list, and that any external funding opportunity that imposes any type of submission limitation is subject to the IU limited submission policy and procedures.

The Special Handling list was created in order to communicate donor restrictions and/or preferences for managing solicitation requests from Indiana University. The list reflects special relationships that exist between donors and the university and includes corporations and foundations that the President's office wishes to review prior to submission in order to coordinate Indiana University's requests to these donors.

The Special Handling List was compiled and is maintained by the Indiana University Foundation office of Corporate and Foundation Relations. Please contact Dee Metaj at 317-278-5644 if you have any questions regarding this list.

IU Authentication is required to view the following attachments:

IUF Special Handling List and Principal Gifts Review Template

 

Office of the Vice Chancellor for Research - ovcr@iupui.edu
Indiana University Purdue University Indianapolis
755 West Michigan Street, UL1140, Indianapolis, IN 46202-2896
Phone: (317) 278-8427

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