IUPUI Homepage
Research Enterprise Newsletter

The Office of the Vice Chancellor for Research (OVCR) publishes the RESEARCH ENTERPRISE to keep the academic community and the community at large informed about research activities, opportunities and development on the IUPUI campus.

Research Offices:
Development
Administration
Compliance
Enterprise Archive


Editor:
Etta Ward

Layout:
Fred Haver


If you have a news item or recent noteworthy research-related achievement that you would like to share, please see the Research Enterprise Submission Guidelines.

Please be aware that not all news items will be deemed appropriate or timely for publication, but each item will be carefully considered.

October 27, 2016

INSIDE THIS ISSUE:

 

FEATURE STORY

Research awards at IUPUI increased by $40.5 million in 2016

Non-IU School of Medicine awards rose by 16 percent

nanosensor researchers

Researchers in the Integrated Nanosystems Development Institute Lab are developing nanosensors to detect the onset of hypoglycemic episodes in people with diabetes.

The Office of the Vice Chancellor for Research at Indiana University-Purdue University Indianapolis has released funding results for fiscal year 2016 showing research awards campuswide totaled $428.9 million, a $40.5 million increase over 2015.

Counting only non-IU School of Medicine awards, the campus received $67.2 million in research awards in 2016, compared to $58.1 million in 2015, a 16 percent increase.

The increase in research awards reflects, in part, the support of the Office of the Vice Chancellor for Research to advance innovative research and creative activity.

Funding awards for 2016 show an increase in National Science Foundation awards, one of the office's strategic goals. NSF funding rose from $5.2 million in 2015 to $7.9 million in 2016.

NSF awards in 2016 included $200,022 for a research team led by the School of Engineering and Technology to overcome problems with one approach to increasing the capacity of lithium ion batteries.

Another National Science Foundation grant will enable researchers at IUPUI to develop a Breathalyzer-type device to detect the onset of hypoglycemia, or low blood sugar episodes, in people with diabetes.

The funding awards underscore efforts by the Office of the Vice Chancellor for Research to develop and expand research programs that address important national and global needs and support economic development of Indiana and the nation.

Other external funding supported research to:

  • Develop information-based tools to help primary care providers improve care for patients with chronic pain, a condition that affects 100 million Americans at a cost of $630 billion annually in health care costs and lost worker productivity.
  • Study the use of the electronic dental record to evaluate the outcome of dental treatments.
  • Study nonmilitary applications of unmanned aerial systems (drone) technology, such as remote imaging for water quality, mosquito habitat mapping, disaster preparation, precision agriculture, and the utilization and analysis of data collected with unmanned aerial systems.

The office helps stimulate faculty research efforts through internal funding programs, events, workshops and proposal development assistance, said Etta Ward, executive director of research development.

"Our office provides proposal-writing seminars that lead to actual submissions, not just generic proposal writing," Ward said. "The seminars take the form of a series of sessions in which researchers come together to discuss specific external funding mechanisms, engage in proposal-writing exercises, review each other's proposals and prepare for submission to the external funding agencies."

The office also focuses its efforts to secure awards through large groups like the IUPUI Arts and Humanities Institute to assist faculty in pursuing funding opportunities through organizations such as the National Endowment for the Arts and private funding sources.

The efforts of one group assembled by the office led to IUPUI becoming the recipient of the first scaffold-free bioprinting robot installed in an academic institution in the United States. The multidisciplinary group has begun exploring a new center of excellence targeting research and development using 3-D printing and bioprinting. This group involves active collaborations among imaging, computational mechanics, biomaterials, orthopedics, cell biology, vascular biology, regeneration, otolaryngology, nanosystems and creative activities in the arts. This has opened up potential partnerships with local 3-D manufacturing partners and with the orthopedic industry.

The office also helps faculty connect to internal sources of seed funding to launch new areas of research or new collaborations. "Our faculty have an abundance of ideas and expertise," said Simon Atkinson, interim vice chancellor for research. "Our office encourages faculty to take advantage of the wealth of resources available in all the schools on the Indianapolis campus to take their projects to the next level."

The efforts of the office don't stop with assisting faculty to secure awards.

The Office of the Vice Chancellor for Research has staff who help connect researchers to industry partners. It also helps faculty and student researchers understand the process to protect and further develop research that has commercial potential and serves as a liaison to the Indiana University Research and Technology Corporation, a not-for-profit agency that assists IU faculty and researchers in realizing the commercial potential of their discoveries.

"Our office works hard to make IUPUI the best possible place for the outstanding faculty, students and staff who are the ones making discoveries that will shape our future," Atkinson said. "The success in securing research funding is just one measure of the vibrancy of the research enterprise here."

 

ANNOUNCEMENTS

IUPUI professor releases latest in series of science-related books for black children

Jomo Mutegi

Jomo Mutegi

Ronnie's Great Idea

Ronnie's Great Idea

A new children's book has been published about an African-American physicist who is a leader in time-travel research, the latest in a series of science-related self-published books for black children.

Titled "Ronnie's Great Idea," the book is about Ronald L. Mallett, who is currently at the University of Connecticut and has a patent on a time-travel machine.

As biographical fiction, the book presents key events in Mallett's life through a fictionalized story that begins with Ronald as a young child and ends with him as a university professor. The story describes how his drive to create a time machine and the support of his family help him overcome challenges he faces.

The book's author, Jomo W. Mutegi, an associate professor of science education in the School of Education at Indiana University-Purdue University Indianapolis, said the book is especially powerful for children of African descent.

"Stories like that of Dr. Mallett are too little known," Mutegi said. "It is difficult to see the power and potential we have as a race when our heroes are not shown and their stories are not told. 'Ronnie's Great Idea' is a powerful departure from the norm. It is a valuable resource for black children and adults alike."

Through Black Kids Read, Mutegi has self-published a series of books that have a common goal, as stated on its website: "At Black Kids Read we want the best for Black children. We believe that Black children should smile and laugh a lot; that they should know they are respected; and that they should have safe educational spaces.

"To help make these beliefs a reality, we produce science-related books for Black children," the statement continues. "Black Kids Read books provide positive uplifting images of Black children and families and feature Black children and families as protagonists."

Writing children's books is Mutegi's night job, so to speak. His day job focuses on research about the participation of people of African descent in STEM (science, technology, engineering and mathematics) fields.

Part of his work, Mutegi said, involves positioning children and their parents to have an appreciation and understanding of human interaction with nature in ways that are meaningful personally and to the larger community of African people.

Mutegi said children spend a lot of time in science classes in schools, but the overwhelming majority of what they learn is removed from what people need to know or will ever use.

"For example, we don't typically learn how sugar is metabolized in the body and how that's different from fats," he said. "We rarely develop a good sense of how to monitor our own health. We do not measure, read and interpret the vital signs that doctors and nurses use as baseline indicators of human health."

That led Mutegi to publish a series of children's books aimed at helping children learn about food origins.

"If you go to an elementary-school classroom, show them a bowl of spaghetti and ask the children where it comes from, they have no idea," he said.

He has also written a book about the history of the buffalo, how it became extinct, and how that impacted the ecosystem and the people who relied on the buffalo.

"While the subjects of the books vary, they are very connected in terms of students' needs," Mutegi said.

"When I sit down to think about a children's book, I consider first what kinds of information students are not likely to receive in school, and second, what information would help them maximize what they do learn in school."

"The books are intended to help students fill in the gaps," Mutegi said.

“In the case of "Ronnie's Great Idea," the book is about a scientist that is doing something almost unimaginable -- time travel," Mutegi said. "But the scientist's life was not atypical, not unlike the lives of many of the children who will read the story."

Changes to NIH Progress Report (RPPR) Submission

Effective November 1, 2016, the Office of Research Administration (ORA) will implement changes regarding the submission of NIH Research Performance Progress Reports (RPPR) for SNAP awards. As of that date, the Principal Investigator (PI) will assume responsibility for submitting RPPRs directly to the NIH.

PIs will be given NIH eRA Commons system permissions to complete and submit the RPPR previously submitted by ORA. The PI will then have the option to delegate editing authority to other individuals within their department. Said delegates will have the ability to edit and upload documents to the RPPR on eRA Commons, however, the PI will be required to review and submit the RPPR.

Your project Grant Consultant will still be available to answer any questions that may arise from this change.

Below are helpful links with guidelines and instructions for submitting an RPPR.

 

FACULTY SPOTLIGHT

From Mentee to Mentor

Silvia Bigatti

IUPUI Associate Professor Silvia Bigatti oversees a research-based summer camp designed to build confidence in Latino teens.

Associate professor of social and behavioral sciences Silvia Bigatti, a native of Argentina, spent her formative years in California and returned to the U.S. in college, transferring to San Diego State University (SDSU). While there, she benefited from the minority-retention Faculty-Student Mentoring Program. Weekly sessions covered such topics as time management, organization and study skills; and peer mentors stayed in close contact with students. In turn, she eventually contributed her own such services there.

In 2000, bringing her newly minted Ph.D. in clinical psychology (behavioral medicine track) from a joint endeavor of SDSU and the University of California, San Diego, to IUPUI, Bigatti taught in the Department of Psychology for nine years, mentoring both graduate and undergraduate students. Commenting that she especially values tiered arrangements, she observes, “It’s a good system, where the ones in training learn to mentor.”

Since 2009 Bigatti has been with the IU Richard M. Fairbanks School of Public Health, where the student investigators she works with are primarily undergraduates, dozens of whom she has guided over the years with support from several initiatives of the Center for Research and Learning (CRL), e.g., the IUPUI Undergraduate Research Opportunities Program (UROP), the Multidisciplinary Undergraduate Research Institute (MURI), the Diversity Scholars Research Program (DSRP), Ivy Tech Community College and IUPUI’s joint Bridges to the Baccalaureate in Central Indiana, as well as several others on campus. Citing a couple of her experiences with Ronald E. McNair Postbaccalaureate Achievement Program scholars, she mentioned Ann Marie Hernández, a McNair alumna who became one of her doctoral mentees. Reflecting on the difference McNair had made in the life of her protégée, Bigatti emphasized, “These programs really, really mean something! She was first-generation; she goes and gets her Ph.D.; and all of the generations after her want to do likewise. It’s an example of how incredibly rewarding mentoring is!”

DSRP scholar and pre-medical student Michelle Ramírez has been conducting research under Bigatti’s tutelage for most of her college career. Noting, “It’s a very synergistic relationship,” the educator describes how, with the assistance of a UROP grant, Michelle made a ten-week trip to Colombia this past summer, which the professor points out, “is an example of the various ways faculty can mentor undergraduates.” In their first year, she endeavors to provide mentees experience with disparate facets, priding herself on giving them, “a pretty good idea of what a research career is like”

What Bigatti most values are, “the close working relationships,” adding, “You become connected with them, and you care about them.” She specifies that what is most gratifying to her is, “when I can help them achieve their dreams and go on to live a life they want,” pointing out, “As they go on to their doctoral programs, this is going to impact the way they practice, working with the community and improving the lives of others.”

 

TRANSLATIONAL RESEARCH IMPACT

Tumors' alternative energy source could become a new target for anti-melanoma therapy

Samisubbu Naidu, PhD

Samisubbu Naidu, PhD

Melanoma tumors switch to an alternative energy system when they develop resistance to chemotherapy, making that alternative system an attractive target for new treatments, according to researchers at Indiana University School of Medicine.

Malignant melanoma is one of the most lethal forms of cancer, responsible for 95 percent of skin cancer-related deaths. When the cancer has not spread, surgery is an effective treatment option. If it has spread, drugs that block the activity of the mutated gene successfully shrink the tumors, but the tumors eventually develop resistance to the drugs, leaving physicians without effective treatment options.

The research, recently published in the Journal of Biological Chemistry, focused on the subtype of malignant melanoma that contains a particular genetic mutation found in nearly 50 percent of such tumors.

Like most cells in the body, cancer cells process glucose to provide the energy needed for cellular activities and proliferation. However, previous research with PET scans has shown that glucose levels drop significantly in melanoma tumor cells as they develop resistance to drugs.

In the new study, researchers led by Samisubbu R. Naidu, PhD, research assistant professor of microbiology and immunology, determined that more than half of malignant melanomas, those carrying the mutant gene, shifted from using glucose to acetate as a main source of energy. The researchers also identified the enzyme responsible for conversion of acetate into energy.

These findings highlight the potential of this enzyme as a novel target for a new anti-melanoma therapy, Dr. Naidu said.

"If we can develop a drug that can effectively inhibit this enzyme, we could extend the life of melanoma patients from months to years," he said.

The study focused on melanoma cells containing a mutant BRAF protein, which directs the cells to proliferate and survive in nutrient-limited environments.

In a series of experiments, the researchers grew melanoma cells in various combinations of nutritional media and found that supplementing the media with acetate enabled the cells to survive and proliferate in the absence of glucose.

Subsequently, it was found that in the absence of glucose, mitochondria, the cellular organelles commonly known as the “powerhouse of the cell,” were increasingly active in the energy production, using acetate as a fuel. One particular enzyme enabled the use of this alternative source of energy. Importantly, by deleting this gene in melanoma cells, the authors showed that melanoma tumor growth in mice was blunted.

Dr. Naidu noted that mutations in the BRAF gene are found in many other types of cancer. Therefore, he said, "The benefits of this discovery may well go beyond melanoma."

Financial support for this research was provided in part by the Indiana Clinical and Translational Sciences Institute Independent Scientist Award, Indiana CTSI Core awards, the Ralph W. and Grace M. Showalter Research Trust as well as funds from Hal E. Broxmeyer, PhD, Distinguished Professor and professor of microbiology and immunology.

In addition to Dr. Naidu and Dr. Broxmeyer, investigators contributing to the work were Alexander J. Lakhter, James Hamilton, Raymond L Konger and Nickolay Brustovetsky, all of IU School of Medicine.

 

OVCR EVENTS AND WORKSHOPS

Advances in Renal Imaging Symposium

November 15 & 16, 2016
IUPUI Campus Center

The primary objective of the Advances in Renal Imaging Symposium is to provide a forum for nephrology researchers and imaging scientists to come together and discuss needed kidney imaging biomarkers and explore the development of imaging technologies designed to address specific renal imaging needs.

This symposium is sponsored by the IUPUI Imaging Research Initiative and OVCR.

* This Symposium is scheduled to precede the American Society of Nephrology (ASN) Kidney Week 2016 in Chicago, IL.

 

RECENT EXTERNAL FUNDING AWARDS

Grants and Awards – September 2016

PI

Agency

Project Title

School

Department

Total

Foroud, Tatiana M

NATIONAL INSTITUTE ON AGING

National Cell Repository for Alzheimer's Disease

MEDICINE

MEDICAL & MOLECULAR GENETICS

$6,893,681

Palakal, Mathew J.

NATIONAL SCIENCE FOUNDATION

Empowering informatics Diversity Enhanced Workforce

INFORMATICS

INFORMATICS

$4,041,077

Vreeman, Rachel Christine

NATIONAL INSTITUTE ALLERGY & INFECTIOUS DISEASES

HIV treatment failure and drug resistance in western Kenyan children

MEDICINE

PED-HEALTH SERVICES RESEARCH

$2,822,275

Pressler, Susan J.

NATIONAL INSTITUTE OF NURSING RESEARCH

Cognitive Intervention to Improve Memory in Heart Failure Patients

NURSING

NURSING

$2,564,957

Dagher, Pierre C.

NATIONAL INSTITUTE OF DIABETES, DIGESTIVE & KIDNEY

Endotoxin preconditioning as a model to uncover protective pathways in sepsis-induced renal injury.

MEDICINE

NEPHROLOGY

$1,871,928

Paydar, Nasser H.

NATIONAL SCIENCE FOUNDATION

Indiana STEM LSAMP

EXECUTIVE MANAGEMENT

EXECUTIVE MANAGEMENT

$1,787,421

Peipert, Jeffrey F

SUSAN THOMPSON BUFFETT FOUNDATION

Evaluation of Prolonged Use of IUD/Implant for Contraception (EPIC Study)

MEDICINE

OBSTETRICS AND GYNECOLOGY

$554,278

Clapp, D Wade

RILEY CHILDREN'S FOUNDATION

Research Scholars, Department of Pediatrics

MEDICINE

PED-CHAIRMAN'S OFFICE GENERAL

$500,000

Territo, Paul R

STRYKER CORPORATION

Early User Evaluation of Robotic-Arm Assisted Total Knee Arthroplasty

MEDICINE

RADIOLOGY & IMAGING SCIENCES

$489,126

Chen, Peng-Sheng

ARRHYTHMOTECH, INC.

Skin Sympathetic Nerve Activity and Cardiac Arrhythmias

MEDICINE

CARDIOLOGY

$403,496

Farlow, Martin Rhys

UNIVERSITY OF SOUTHERN CALIFORNIA

Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study)

MEDICINE

NEUROLOGY

$288,000

Bodenhamer, David J

DOMESTIC VIOLENCE NETWORK

Data Integration and Analysis Services for DVN

LIBERAL ARTS

POLIS
CENTER

$209,500

Lamb, Bruce Timothy

BRIGHTFOCUS FOUNDATION

The Role of TREM2 in AD Tauopathy

MEDICINE

STARK NEUROSCIENCES RES INST

$175,000

Hickman, Susan E

RETIREMENT RESEARCH FOUNDATION

The Quality of Advance Care Planning Documentation in the Nursing Home

NURSING

NURSING

$161,779

Dixon, Brian Edward

INDIANA STATE DEPARTMENT OF HEALTH

Leveraging a statewide registry of traumatic brain and spinal cord injuries to inform the surveillance and treatment of populations in Indiana

PUBLIC HEALTH

EPIDEMIOLOGY

$157,417

Deng, Lingxiao

CRAIG H NEILSEN FOUNDATION

Role of propriospinal tract in functional recovery of contusive spinal cord

MEDICINE

NEUROLOGICAL SURGERY

$150,000

Bonewald, Lynda Faye

UNIVERSITY OF MISSOURI-KANSAS CITY

Osteocyte Regulation of Bone Muscle with Age - Core A: Administrative Core & Subproject 1: Muscle Regulation of Osteoblast/Osteocyte Function in Young compared with Aged Animals

MEDICINE

ANATOMY & CELL BIOLOGY

$121,327

Curtis, Edward E

NATIONAL ENDOWMENT FOR THE HUMANITIES

Muslim American Identities, Past and Present

LIBERAL ARTS

LIBERAL ARTS

$108,969

Pfeifle, Andrea L

INDIANA UNIVERSITY HEALTH

Integration of Interprofessional Education and Practice to Provide Clinic Oversight, Enhance Teamwork, and Achieve Continuous Quality Improvement at the Indiana University Student Outreach Clinic

MEDICINE

 

$100,000

Crabb, David William

INDIANA UNIVERSITY HEALTH

Comprehensive Lifestyle Medicine Curriculum for Internal Medicine Residents

MEDICINE

GASTROENTEROLOGY

$100,000

Ceppa, DuyKhanh Pham

INDIANA UNIVERSITY HEALTH

Lung cancer screening: a teachable moment for smoking cessation

MEDICINE

CARDIOSURGERY

$100,000

Doshi, Simit M

INDIANA UNIVERSITY HEALTH

Effect of secondary hyperparathyroidism on peripheral nerve function in end stage renal disease (ESRD) population.

MEDICINE

NEPHROLOGY

$100,000

 

CURRENT EXTERNAL FUNDING OPPORTUNITIES

Funding opportunities in this section include selected current grant announcements from federal agencies for new initiatives and changes to existing programs. Announcements with limited scope are not listed here but instead are sent directly to IUPUI School Deans. For comprehensive coverage of funding opportunities, please use the links below to search online tools.

NATIONAL INSTITUTES OF HEALTH

Advancing the Science of Geriatric Palliative Care (R21): This opportunity encourages applications focused on palliative care in geriatric populations and emphasizes studies in a variety of settings that include ambulatory care hospitals (and specific sites within hospitals facilities, and short- and long-term care facilities. However, hospice and end-of-life settings are not included within the scope of this opportunity. Rather, this vehicle highlights research on palliative care in settings and at time points earlier in geriatric patients' disease or disability trajectories. Types of studies may include observational, quasi-experimental, or interventional studies using primary data collection and/or secondary analyses. Leveraging on-going cohorts, intervention studies, networks, data and specimen repositories, and other existing resources and infrastructure are encouraged. Deadline: February16, 2017.
http://grants.nih.gov/grants/guide/pa-files/PA-13-355.html

Implementation Science Research to Improve Dental, Oral & Craniofacial Health (UO1): This Opportunity encourages investigators to submit research grant applications on the use of implementation science strategies aimed at reducing the time between establishment of the evidence-base of interventions/policies/practices and widespread uptake and adoption for dental/oral/craniofacial health. This vehicle requires applications be designed to address implementation of dental/oral/craniofacial evidence-based interventions at multiple levels. This includes, but is not limited to, research to understand the behavior of dental/oral/craniofacial health professionals and support staff, dental/oral/craniofacial health organizations, dental/oral/craniofacial health consumers and family members, and policymakers in context as key variables in the adoption, implementation and sustainability of evidence-based interventions and guidelines. Examples of evidence-based interventions include those from the Institute of Medicine, Community Guide to Preventive Services, U.S. Preventive Services Task Force, American Dental Association, American Association of Public Health Dentistry, American Academy of Periodontology, and other clinical and professional societies. Deadlines: Letter of Intent: Jan. 21, 2017; Application: February 21, 2017.
http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-18-001.html

Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind & Body Interventions (R43/R44): This opportunity supports Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that will develop and/or validate devices or electronic systems that can: 1) monitor biologically- or behaviorally-based processes applicable to mind and body interventions or 2) be used to assist in optimizing the practice or increasing the efficacy of mind and body interventions. The applications should: 1) lead to the development of new technologies, 2) adapt existing innovative technologies, devices and/or electronic systems, 3) repurpose existing devices and electronic systems, or 4) conduct testing of single or combined components of an integrated, long term, automated, wearable monitoring, stimulation device or electronic system in order to monitor or enhance the mechanistic processes or functional outcomes of mind and body interventions. For the purposes of this vehicle, mind and body interventions are defined as non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), or combined mind and body meditative movement approaches (e.g., yoga, tai-chi, qigong). Deadline: April 5, 2017.
http://grants.nih.gov/grants/guide/pa-files/PAS-17-022.html

NATIONAL SCIENCE FOUNDATION

Transdisciplinary Research in Principles of Data Science (TRIPODS): This opportunity aims to bring together the statistics, mathematics, and theoretical computer science communities to develop the theoretical foundations of data science through integrated research and training activities. Phase I, described in this solicitation, will support the development of small collaborative Institutes. Phase II (to be described in an anticipated future solicitation, subject to availability of funds) will support a smaller number of larger Institutes, selected from the Phase I Institutes via a second competitive proposal process. All TRIPODS Institutes must involve significant and integral participation by all three of the aforementioned communities. Deadlines: Letter of Intent: January 19, 2017; Application: March 15, 2017
https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=505347

Innovative Technology Experiences for Students & Teachers (ITEST): ITEST is a program that promotes PreK-12 student interests and capacities to participate in the STEM and information and communications technology (ICT) workforce of the future. To achieve this objective, ITEST supports the development, implementation, and selective spread of innovative strategies for engaging students in experiences that: 1) increase student awareness of STEM and ICT careers; 2) motivate students to pursue the education necessary to participate in those careers; and/or 3) provide students with technology-rich experiences that develop their knowledge of related content and skills needed for the STEM workforce. ITEST projects may adopt an interdisciplinary focus on multiple STEM domains, focus on a single domain, or focus on one or more sub-disciplines within a domain. ITEST projects must involve students, and may also include teachers. The ITEST program is especially interested in broadening participation of students from traditionally underrepresented groups in STEM fields and related education and workforce domains. ITEST supports two project types: Strategies projects and SPrEaD (Successful Project Expansion and Dissemination) projects. Strategies projects support the design, implementation, and testing of innovative educational experiences that support the objectives of the ITEST program. SPrEaD projects support the wider and broader testing and dissemination of promising strategies to generate evidence and greater understanding of contextual factors that operate to enhance, moderate, or constrain anticipated project impacts. Deadline: August 9, 2017.
http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5467

Expeditions in Computing: This program was created to provide the Computer and Information Science and Engineering (CISE) community with the opportunity to pursue ambitious, fundamental research agendas that promise to define the future of computing and information. In planning Expeditions projects, investigators are encouraged to come together within or across departments or institutions to combine their creative talents in the identification of compelling, transformative research agendas that promise disruptive innovations for years to come. Expeditions represent some of the largest single investments currently made by the directorate. With awards funded at levels that promote the formation of research teams, CISE recognizes that concurrent research advances in multiple fields or sub-fields are often necessary to stimulate deep and enduring outcomes. The Expeditions program has three goals: 1)To catalyze far-reaching research explorations motivated by deep scientific questions or hard problems in the computing and information fields and/or by compelling applications that promise significant societal benefits; these explorations may exploit advanced cyberinfrastructure to enable and accelerate discovery and innovation across disciplines; they should be ambitious and potentially transformative, but also focused toward achieving concrete progress given the anticipated duration and funding levels; 2) To inspire current and future generations of Americans, especially those from under-represented groups, to pursue rewarding careers in computer and information science and engineering; and 3) To stimulate significant research and education outcomes that, through effective knowledge transfer mechanisms, promise scientific, economic and/or other societal benefits. Deadlines: Preliminary Proposal: April 25, 2018; Full Proposal: Jan. 16, 2019. March 22, 2017.
http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503169

U.S. DEPT. OF DEFENSE

INTERfering and Co-Evolving Prevention & Therapy (INTERCEPT): The goal of the INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program is to explore and evaluate virus-based therapeutic interfering particles (TIPs) that parasitize, interfere, and co-evolve with viral targets as a means of adaptively preventing, controlling, and eliminating acute or chronic infection.

The novel path explored in this program is based upon previously reported Defective Interfering Particles (DIPs), viral-derived particles with partially deleted genomes that arise during a natural infection. DIPs lack genes encoding replication enzymes and capsid proteins, and thus require co-infection with the wildtype parent virus to replicate and mobilize. 1) DIPs have been isolated from numerous viral infections and shown to interfere with the replication and packaging processes through stoichiometric competition for essential viral components. 2) It has been suggested that DIPs may have therapeutic and protective potential and may serve as a broad range treatment approach to combat respiratory infections. For example, a cloned Influenza-A DIP was effective in protecting from infection by Influenza-A, as well as by heterologous respiratory viruses in small animal models. 3) In addition, given their transmission potential, it has been proposed that interfering viral particles may serve as anti-viral therapies to reduce disease incidence and thus control epidemics.

The INTERCEPT program aims to explore and evaluate the potential of TIPs as a therapeutic and/or preventive approach for the long term control of a broad range of fast-evolving viruses. The program will address the key technical challenges and risks of TIP safety, efficacy, long-term co-evolution, and generalizability, by leveraging novel molecular and genetic design tools, high throughput genomic technologies, and advanced computational methods in a multidisciplinary, multi-team effort.

To explore the TIP concept as a potential therapeutic and/or preventive platform that can keep pace with fast-evolving pathogens, INTERCEPT will address four fundamental questions: 1) Safety & efficacy: Can TIPs be built that are safe and out-compete the pathogen to control infections short-term? 2) Co-evolution: Can TIPs evolve and keep pace with evolving pathogens to control an infection long-term? 3) Population-scale efficacy: Can TIPs co-transmit alongside pathogen to help control the spread of infectious disease across populations? 4) Generalizability: Can the TIP concept be extended across multiple viruses and for multiple acute and chronic infectious diseases? Deadline: July 7, 2017.
http://www.grants.gov/web/grants/view-opportunity.html?oppId=283354

Data-Driven Discovery of Models (D3M): This opportunity solicits innovative research proposals in the area of automated model discovery systems that create empirical models of real, complex processes from data. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.

D3M aims to develop automated model discovery systems that enable users with subject matter expertise but no data science background to create empirical models of real, complex processes. This capability will enable subject matter experts to create empirical models without the need for data scientists, and will increase the productivity of expert data scientists via automation. The automated model discovery systems developed by the D3M Program will be tested on real-world problems that will progressively get harder during the course of the program.

The D3M program is divided into three technical areas (TAs): TA1: A library of selectable primitives. A discoverable archive of data modeling primitives will be developed to serve as the basic building blocks for complex modeling pipelines. TA2: Automated composition of complex models. Techniques will be developed for automatically selecting model primitives and for composing selected primitives into complex modeling pipelines based on user-specified data and outcome(s) of interest. TA3: Human-model interaction that enables curation of models by subject matter experts. A method and interface will be developed to facilitate human-model interaction that enables formal definition of modeling problems and curation of automatically constructed models by users who are not data scientists. Deadlines: Abstract Submission: June 24, 2017; Proposal: Aug. 12, 2017.
http://www.grants.gov/web/grants/view-opportunity.html?oppId=284657

NOTE: All faculty, researchers, and scientists on continuing contracts at IU interested in applying for Department of Defense funding are eligible for assistance by the consulting firm--Cornerstone Government Affairs-arranged by the Vice President for Research. Those interested in securing assistance from Cornerstone must submit a 2 page summary of their research project and a CV or biosketch to the VP for Research Office at vpr@iu.edu. Prior to submission, the IUPUI Office of the Vice Chancellor for Research is offering assistance with the 2 page summaries. For more information, contact Ann Kratz akratz@iupui.edu.

 

IDENTIFYING FUNDING OPPORTUNITIES

On-line search tools are available to IUPUI investigators who are interested in identifying funding opportunities in their areas of interest.

Pivot (formerly COS): Pivot is a primary on-line search tool for identifying funding opportunities. To take advantage of this tool, register at https://pivot.cos.com/register. Once you have completed the short registration process, you can personalize your search by selecting the option entitled “launch your workbench”. You can access federal, local, corporate, foundation, nonprofit and other funding opportunities using key terms and save the results of up to 20 searches and have them delivered to you weekly via email.

National Institutes of Health (NIH) “NIH Guide”: To take advantage of this search tool, register at http://grants.nih.gov/grants/guide/listserv.htm. It allows you to receive discipline specific funding opportunities that are delivered to you weekly via email.

National Science Foundation (NSF) “MyNSF”:To take advantage of this search tool, register at http://service.govdelivery.com/service/multi_subscribe.html?
code=USNSF&custom_id=823
. It allows you to receive discipline specific funding opportunities that are delivered to you weekly via email.

Federal Business Opportunities “FedBizOpps”: FedBizOpps is the single government point-of-entry for Federal government procurement opportunities over $25,000. To take advantage of this search tool, visit https://www.fbo.gov. Opportunities found at this site include, but are not limited to, presolicitations and special notices for research and service contracts for specific projects and some national centers and surveys that would not be found in Grants.gov and may not be found in the Community of Science.

Limited Submission Funding Opportunities:
Many federal agencies and foundations offer grants, awards and fellowships that limit the number of applications that can come from one institution or require special handling. In order to comply with agency and foundation guidelines and increase the chances of Indiana University (IU) succeeding in such limited submissions and special handling opportunities, IU policies and procedures are in place and are utilized by the Office of the Vice Chancellor for Research and other IU research offices to facilitate internal coordination and competitions.

Individuals interested in responding to limited submission opportunities must inform the Office of the Vice Chancellor for Research about their intent to apply to a given limited submission opportunity, such that they can be included in the internal review and selection process. Failure to do so may disqualify individuals from consideration for submission to the funding opportunity.

Individuals interested in a limited submission opportunity or have any questions about the internal coordination process, contact Etta Ward at emward@iupui.edu or 317-278-8427. For a description of upcoming limited submission funding opportunities, as well as guidelines and application forms, go to: http://research.iu.edu/limited_sub.shtml. Please note that this is not a comprehensive list, and that any external funding opportunity that imposes any type of submission limitation is subject to the IU limited submission policy and procedures.

 

Office of the Vice Chancellor for Research - ovcr@iupui.edu
Indiana University Purdue University Indianapolis
755 West Michigan Street, UL1140, Indianapolis, IN 46202-2896
Phone: (317) 278-8427

Subscribe or Unsubscribe

spacergraphic spacergraphic spacergraphic spacergraphic spacergraphic