CANCER RESEARCH UK (CRUK)
Grand Challenge Awards: These awards are the most ambitious cancer research grants in the world. They're intended to catalyze a revolution in how we prevent, diagnose, and treat cancer by providing the freedom to undertake innovative, game-changing research. CRUK are looking for applications from interdisciplinary teams with novel, exciting ways of solving one of seven Grand Challenges, which together encompass some of the most important unanswered questions in cancer research. If applicants can convince CRUK they're on to something extraordinary, CRUK will give the team up to $15M to prove it. Cancer Research UK is seeking scientific adventurers.
The Grand Challenges are: 1) Develop vaccines to prevent non-viral cancers, 2) Eradicate EBV-induced cancers, 3) Discover how unusual mutation patterns are induced by cancer-causing events, 4) Distinguish between lethal cancers that need treatment and non-lethal ones that don't, 5) Find a way of mapping tumors at the molecular and cellular levels, 6) Develop innovative approaches to target the cancer super-controller MYC, and 7) Deliver biologically active macromolecules to any and all cells. Deadlines: Letter of Intent: Feb. 12, 2017; Application: July 31, 2017.
Grand Challenge Awards
NATIONAL INSTITUTES OF HEALTH
Advancing the Science of Geriatric Palliative Care (R21): This opportunity encourages applications focused on palliative care in geriatric populations and emphasizes studies in a variety of settings that include ambulatory care hospitals (and specific sites within hospitals facilities, and short- and long-term care facilities. However, hospice and end-of-life settings are not included within the scope of this opportunity. Rather, this vehicle highlights research on palliative care in settings and at time points earlier in geriatric patients' disease or disability trajectories. Types of studies may include observational, quasi-experimental, or interventional studies using primary data collection and/or secondary analyses. Leveraging on-going cohorts, intervention studies, networks, data and specimen repositories, and other existing resources and infrastructure are encouraged. Deadline: February16, 2017.
Implementation Science Research to Improve Dental, Oral & Craniofacial Health (UO1): This Opportunity encourages investigators to submit research grant applications on the use of implementation science strategies aimed at reducing the time between establishment of the evidence-base of interventions/policies/practices and widespread uptake and adoption for dental/oral/craniofacial health. This vehicle requires applications be designed to address implementation of dental/oral/craniofacial evidence-based interventions at multiple levels. This includes, but is not limited to, research to understand the behavior of dental/oral/craniofacial health professionals and support staff, dental/oral/craniofacial health organizations, dental/oral/craniofacial health consumers and family members, and policymakers in context as key variables in the adoption, implementation and sustainability of evidence-based interventions and guidelines. Examples of evidence-based interventions include those from the Institute of Medicine, Community Guide to Preventive Services, U.S. Preventive Services Task Force, American Dental Association, American Association of Public Health Dentistry, American Academy of Periodontology, and other clinical and professional societies. Deadlines: Letter of Intent: Jan. 21, 2017; Application: February 21, 2017.
Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind & Body Interventions (R43/R44): This opportunity supports Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that will develop and/or validate devices or electronic systems that can: 1) monitor biologically- or behaviorally-based processes applicable to mind and body interventions or 2) be used to assist in optimizing the practice or increasing the efficacy of mind and body interventions. The applications should: 1) lead to the development of new technologies, 2) adapt existing innovative technologies, devices and/or electronic systems, 3) repurpose existing devices and electronic systems, or 4) conduct testing of single or combined components of an integrated, long term, automated, wearable monitoring, stimulation device or electronic system in order to monitor or enhance the mechanistic processes or functional outcomes of mind and body interventions. For the purposes of this vehicle, mind and body interventions are defined as non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), or combined mind and body meditative movement approaches (e.g., yoga, tai-chi, qigong). Deadline: April 5, 2017.
Elucidation of Mechanisms of Radiation-Induced Endovascular Injury and Development of Treatments/Mitigators for Radiation-Induced Endothelial Cell and Vascular Dysfuction (UO1): The NIAID Radiation/Nuclear Countermeasures Development Program supports extramural research to develop safe and effective radiological/nuclear medical countermeasures for clinical use under emergency situations. This program spans basic through applied research. The role of the endovascular network in radiation injury pathogenesis is not well understood; however, the importance of this biological system in the observed multi-organ dysfunction and failure that occurs following radiation exposure has recently been established. This opportunity provides an opportunity for academic, industry and government laboratory researchers to address gaps in the understanding of the pathophysiology of radiation injury in the vasculature, and how this damage contributes to overall mortality following radiation exposure. Deadlines: Letter of Intent: October 10, 2016; Application: November 10, 2016. http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-16-053.html
Exploratory Clinical Trials-Arthritis & Musculoskeletal/Skin Diseases (R21): The purpose of this opportunity is to support and accelerate human epigenomic investigations focused on identifying and characterizing the mechanisms by which social experiences at various stages in life, both positive and negative, affect gene function and thereby influence health trajectories or modify disease risk in racial/ethnic minority and health disparity populations. Deadline: March 01, 2017. http://grants.nih.gov/grants/guide/pa-files/PAR-14-192.html
Pre-Application: Research Innovation for Scientific Knowledge (RISK) for Skin & Rheumatic Diseases (X02): This initiative focuses on innovative research within the NIAMS mission by encouraging applicants to pursue unusual observations, test imaginative hypotheses, investigate creative concepts, and build ground-breaking paradigms, all of which deviate significantly from prevailing theories or practice. The RISK program is designed to encourage the submission of projects that are considered too risky, premature, controversial, or unconventional for other NIH mechanisms. RISK intends to support disease-focused translational studies, up to, but not including, human studies. RISK R61/R33s are not intended to support clinical trials. RISK will support either musculoskeletal or skin/rheumatic diseases, but skin/rheumatic proposals are encouraged.
This pre-application is the recommended (not required) first step in the application process for the companion R61/R33. Potential applicants need to read both. Pre-applications evaluated as highly innovative and most relevant to the RISK program will be invited to submit an R61/R33 application. Deadlines: Letter of Intent: Sept. 04, 2016; Application: October 04, 2016.
NATIONAL SCIENCE FOUNDATION
Transdisciplinary Research in Principles of Data Science (TRIPODS): This opportunity aims to bring together the statistics, mathematics, and theoretical computer science communities to develop the theoretical foundations of data science through integrated research and training activities. Phase I, described in this solicitation, will support the development of small collaborative Institutes. Phase II (to be described in an anticipated future solicitation, subject to availability of funds) will support a smaller number of larger Institutes, selected from the Phase I Institutes via a second competitive proposal process. All TRIPODS Institutes must involve significant and integral participation by all three of the aforementioned communities. Deadlines: Letter of Intent: January 19, 2017; Application: March 15, 2017
Innovative Technology Experiences for Students & Teachers (ITEST): ITEST is a program that promotes PreK-12 student interests and capacities to participate in the STEM and information and communications technology (ICT) workforce of the future. To achieve this objective, ITEST supports the development, implementation, and selective spread of innovative strategies for engaging students in experiences that: 1) increase student awareness of STEM and ICT careers; 2) motivate students to pursue the education necessary to participate in those careers; and/or 3) provide students with technology-rich experiences that develop their knowledge of related content and skills needed for the STEM workforce. ITEST projects may adopt an interdisciplinary focus on multiple STEM domains, focus on a single domain, or focus on one or more sub-disciplines within a domain. ITEST projects must involve students, and may also include teachers. The ITEST program is especially interested in broadening participation of students from traditionally underrepresented groups in STEM fields and related education and workforce domains. ITEST supports two project types: Strategies projects and SPrEaD (Successful Project Expansion and Dissemination) projects. Strategies projects support the design, implementation, and testing of innovative educational experiences that support the objectives of the ITEST program. SPrEaD projects support the wider and broader testing and dissemination of promising strategies to generate evidence and greater understanding of contextual factors that operate to enhance, moderate, or constrain anticipated project impacts. Deadline: August 9, 2017.
Expeditions in Computing: This program was created to provide the Computer and Information Science and Engineering (CISE) community with the opportunity to pursue ambitious, fundamental research agendas that promise to define the future of computing and information. In planning Expeditions projects, investigators are encouraged to come together within or across departments or institutions to combine their creative talents in the identification of compelling, transformative research agendas that promise disruptive innovations for years to come. Expeditions represent some of the largest single investments currently made by the directorate. With awards funded at levels that promote the formation of research teams, CISE recognizes that concurrent research advances in multiple fields or sub-fields are often necessary to stimulate deep and enduring outcomes. The Expeditions program has three goals: 1)To catalyze far-reaching research explorations motivated by deep scientific questions or hard problems in the computing and information fields and/or by compelling applications that promise significant societal benefits; these explorations may exploit advanced cyberinfrastructure to enable and accelerate discovery and innovation across disciplines; they should be ambitious and potentially transformative, but also focused toward achieving concrete progress given the anticipated duration and funding levels; 2) To inspire current and future generations of Americans, especially those from under-represented groups, to pursue rewarding careers in computer and information science and engineering; and 3) To stimulate significant research and education outcomes that, through effective knowledge transfer mechanisms, promise scientific, economic and/or other societal benefits. Deadlines: Preliminary Proposal: April 25, 2018; Full Proposal: Jan. 16, 2019. March 22, 2017.
Elementary Particle Physics – Experiment (EPP): At the NSF, particle physics is supported by four programs within the Division of Physics: (1) the Theory program, which includes fundamental research on the forces of nature and the early history of the universe as well as support for the experimental program by providing guidance and analysis for high energy experiments; (2) the Elementary Particle Physics (EPP) program, which supports particle physics at accelerators; (3) the Particle Astrophysics (PA) program, which supports non-accelerator experiments; and (4) the new Accelerator Science program which supports research at universities into the educational and discovery potential of basic accelerator physics.
EPP also supports advances in detector development and new methods of utilizing distributed computing in support of collaborative research, for example, grid development, both nationally and internationally. The program also engages K-12 educators, who participate in experiments with university scientists, staff and students. Deadline: October 26, 2017
Developmental and Learning Sciences (DLS): DLS supports fundamental research that increases our understanding of cognitive, linguistic, social, cultural, and biological processes related to children's and adolescents' development and learning. Research supported by this program will add to our basic knowledge of how people learn and the underlying developmental processes that support learning, social functioning, and productive lives as members of society.
DLS supports research that addresses developmental processes within the domains of cognitive, social, emotional, and motor development using any appropriate populations for the topics. The program also supports research investigating factors that impact development change including family, peers, school, community, culture, media, physical, genetic, and epigenetic influences. Additional priorities include research that: incorporates multidisciplinary, multi-method, microgenetic, and longitudinal approaches; develops new methods, models, and theories for studying learning and development; includes participants from a range of ethnicities, socioeconomic backgrounds, and cultures; and integrates different processes (e.g., learning, memory, emotion), levels of analysis (e.g., behavioral, social, neural), and time scales (e.g. infancy, middle childhood, adolescence). Deadline: January 7, 2017. https://www.nsf.gov/funding/pgm_summ.jsp?pims_id=8671
High-Risk Research in Biological Anthropology & Archeology (HRRBAA): Anthropological research may be conducted under unusual circumstances, often in distant locations. As a result the ability to conduct potentially important research may hinge on factors that are impossible to assess from a distance and some projects with potentially great payoffs may face difficulties in securing funding. This program gives small awards that provide investigators with the opportunity to assess the feasibility of an anthropological research project. The information gathered may then be used as the basis for preparing a more fully developed research program. Projects which face severe time constraints because of transient phenomena or access to materials may also be considered. Deadline: Continuous. http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=5319
U.S. DEPT. OF DEFENSE
INTERfering and Co-Evolving Prevention & Therapy (INTERCEPT): The goal of the INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program is to explore and evaluate virus-based therapeutic interfering particles (TIPs) that parasitize, interfere, and co-evolve with viral targets as a means of adaptively preventing, controlling, and eliminating acute or chronic infection.
The novel path explored in this program is based upon previously reported Defective Interfering Particles (DIPs), viral-derived particles with partially deleted genomes that arise during a natural infection. DIPs lack genes encoding replication enzymes and capsid proteins, and thus require co-infection with the wildtype parent virus to replicate and mobilize. 1) DIPs have been isolated from numerous viral infections and shown to interfere with the replication and packaging processes through stoichiometric competition for essential viral components. 2) It has been suggested that DIPs may have therapeutic and protective potential and may serve as a broad range treatment approach to combat respiratory infections. For example, a cloned Influenza-A DIP was effective in protecting from infection by Influenza-A, as well as by heterologous respiratory viruses in small animal models. 3) In addition, given their transmission potential, it has been proposed that interfering viral particles may serve as anti-viral therapies to reduce disease incidence and thus control epidemics.
The INTERCEPT program aims to explore and evaluate the potential of TIPs as a therapeutic and/or preventive approach for the long term control of a broad range of fast-evolving viruses. The program will address the key technical challenges and risks of TIP safety, efficacy, long-term co-evolution, and generalizability, by leveraging novel molecular and genetic design tools, high throughput genomic technologies, and advanced computational methods in a multidisciplinary, multi-team effort.
To explore the TIP concept as a potential therapeutic and/or preventive platform that can keep pace with fast-evolving pathogens, INTERCEPT will address four fundamental questions: 1) Safety & efficacy: Can TIPs be built that are safe and out-compete the pathogen to control infections short-term? 2) Co-evolution: Can TIPs evolve and keep pace with evolving pathogens to control an infection long-term? 3) Population-scale efficacy: Can TIPs co-transmit alongside pathogen to help control the spread of infectious disease across populations? 4) Generalizability: Can the TIP concept be extended across multiple viruses and for multiple acute and chronic infectious diseases? Deadline: July 7, 2017.
Data-Driven Discovery of Models (D3M): This opportunity solicits innovative research proposals in the area of automated model discovery systems that create empirical models of real, complex processes from data. Proposed research should investigate innovative approaches that enable revolutionary advances in science, devices, or systems. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
D3M aims to develop automated model discovery systems that enable users with subject matter expertise but no data science background to create empirical models of real, complex processes. This capability will enable subject matter experts to create empirical models without the need for data scientists, and will increase the productivity of expert data scientists via automation. The automated model discovery systems developed by the D3M Program will be tested on real-world problems that will progressively get harder during the course of the program.
The D3M program is divided into three technical areas (TAs): TA1: A library of selectable primitives. A discoverable archive of data modeling primitives will be developed to serve as the basic building blocks for complex modeling pipelines. TA2: Automated composition of complex models. Techniques will be developed for automatically selecting model primitives and for composing selected primitives into complex modeling pipelines based on user-specified data and outcome(s) of interest. TA3: Human-model interaction that enables curation of models by subject matter experts. A method and interface will be developed to facilitate human-model interaction that enables formal definition of modeling problems and curation of automatically constructed models by users who are not data scientists. Deadlines: Abstract Submission: June 24, 2017; Proposal: Aug. 12, 2017.
Young Investigator Program (YIP): The Office of Naval Research announces its Young Investigator Program to identify and support academic scientists and engineers who have recently received Ph.D. or equivalent degrees and who show exceptional promise for doing creative research. The objectives of this program are to attract outstanding faculty members of institutions of higher education to the Navy's research program, to support their research, and to encourage their teaching and research careers. Deadline: November 04, 2016.
Minerva Research Initiative: The Minerva Research Initiative emphasizes questions of strategic importance to U.S. national security policy. It seeks to increase the Department's intellectual capital in the social sciences and improve its ability to address future challenges and build bridges between the Department and the social science community. Minerva brings together universities and other research institutions around the world and supports multidisciplinary and cross-institutional projects addressing specific topic areas determined by the Department of Defense. The Minerva program aims to promote research in specific areas of social science and to promote a candid and constructive relationship between DOD and the social science academic community.
The Minerva Research Initiative competition is for research related to the following 5 topics and associated subtopic: 1) Identity, Influence, and Mobilization; 2) Contributors to Societal Resilience and Change; 3) Power and Deterrence; 4) Analytical methods and metrics for security research; and 5) Innovations in National Security, Conflict, and Cooperation. Deadlines: White Paper: February 27, 2017; Application: June 17, 2017.
NOTE: All faculty, researchers, and scientists on continuing contracts at IU interested in applying for Department of Defense funding are eligible for assistance by the consulting firm--Cornerstone Government Affairs-arranged by the Vice President for Research. Those interested in securing assistance from Cornerstone must submit a 2 page summary of their research project and a CV or biosketch to the VP for Research Office at firstname.lastname@example.org. Prior to submission, the IUPUI Office of the Vice Chancellor for Research is offering assistance with the 2 page summaries. For more information, contact Ann Kratz email@example.com.